Molecular Mechanisms of Hypothalamic Insulin Resistance
نویسندگان
چکیده
منابع مشابه
[Molecular Mechanisms of Insulin Resistance: An Update].
The biological actions of insulin are initiated by activating its membrane receptor, which triggers multiple signaling pathways to mediate their biological actions. Due to the importance of metabolic regulation and promoting functions of cell growth and proliferation, insulin actions are highly regulated to promote proper metabolic functioning and energy balance. If these mechanisms are altered...
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Insulin resistance refers to reduced sensitivity of organs to insulin-initiated biologic processes that result in metabolic defects. Insulin resistance is common in patients with end-stage renal disease but also occurs in patients with chronic kidney disease (CKD), even when the serum creatinine is minimally increased. Following insulin binding to its receptor, auto-phosphorylation of the insul...
متن کاملMolecular mechanisms of insulin resistance that impact cardiovascular biology.
Insulin resistance is concomitant with type 2 diabetes, obesity, hypertension, and other features of the metabolic syndrome. Because insulin resistance is associated with cardiovascular disease, both scientists and physicians have taken great interest in this disorder. Insulin resistance is associated with compensatory hyperinsulinemia, but individual contributions of either of these two condit...
متن کاملMolecular Mechanisms of Insulin Resistance in Chronic Liver Disease
Index 1. Introduction 6 1.1. Hepatitis C Virus Infection 6 Epidemiology and natural history of hepatitis C 6 The Hepatitis C Virus 6 Insulin Resistance in chronic hepatitis C 7 1.2. Non alcoholic fatty liver disease (NAFLD) 8 1.3. Overexpression of PP2Ac in chronic hepatitis C 8 Interferon (IFN) signaling is inhibited in chronic hepatitis C 8 Protein Phosphatase 2A (PP2A) 8 Upregulation of PP2A...
متن کاملHypothalamic resistin induces hepatic insulin resistance.
Circulating resistin stimulates endogenous glucose production (GP). Here, we report that bi-directional changes in hypothalamic resistin action have dramatic effects on GP and proinflammatory cytokine expression in the liver. The infusion of either resistin or an active cysteine mutant in the third cerebral ventricle (icv) or in the mediobasal hypothalamus stimulated GP independent of changes i...
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ژورنال
عنوان ژورنال: International Journal of Molecular Sciences
سال: 2019
ISSN: 1422-0067
DOI: 10.3390/ijms20061317